Dissociation between adipose tissue fluxes and lipogenic gene expression in ob/ob mice

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Dissociation between adipose tissue fluxes and lipogenic gene expression in ob/ob mice.

Recent evidence has been presented that expression of lipogenic genes is downregulated in adipose tissue of ob/ob mice as well as in human obesity, suggesting a functionally lipoatrophic state. Using (2)H(2)O labeling, we measured three adipose tissue biosynthetic processes concurrently: triglyceride (TG) synthesis, palmitate de novo lipogenesis (DNL), and cell proliferation (adipogenesis). To ...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism

سال: 2007

ISSN: 0193-1849,1522-1555

DOI: 10.1152/ajpendo.00309.2005